This is a very short blog post because more and more VMware customers and partners are asking me the same question ...
"Why NUMA matters?"
If you want to know more I would highly recommend reading Frank Denneman's detailed blog posts or books about NUMA, however, the table below is worth 1000 words.
Local memory access latency is ~ 75 ns.
Remote memory access latency is ~ 132 ns.
A ~ 40% positive impact on performance is worth to incorporate NUMA considerations in your data center infrastructure design.
If you prefer a comprehensive presentation, Frank Denneman should speak on VMworld 2020 about NUMA in session "60 Minutes of NUMA [HCP2453]".